Application of 914637-31-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 914637-31-3 as follows.
4.2 g (181 mmol) of sodium in small pieces were added gradually to a solution of25 g (151 mmol) of(3-fluoro-5-methoxyphenyl)-acetonitrile in 200 mL of diethyl carbonate in such a manner that the temperature remained at approximately 100C.Thereafter, the reaction mixture was heated to reflux for 1 hr. After evaporation under reduced pressure, the mixture was treated with cooled water. The solution was acidifiedwith acetic acid and extracted with EA. The combined organic extracts were dried andevaporated. The residue was purified by silica gel (EA: PE/1 :10) to give 23 g of the title compound as light brown oil (yield: 64%).LC-MS: m/z 238 (M+H); RT=1.72 min/2.5 min.
According to the analysis of related databases, 914637-31-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBVIE DEUTSCHLAND GMBH & CO. KG; ABBVIE INC.; GENESTE, Herve; OCHSE, Michael; DRESCHER, Karla; JAKOB, Clarissa; WO2014/27078; (2014); A1;,
Nitrile – Wikipedia,
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