Application of 105-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105-34-0, name is Methyl 2-cyanoacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of aromatic aldehyde (10 mmol) and active methylene compound(10 mmol) in 10 mL ethanol was introduced in a 20 mL heavy walled pearshapedtwo-necked flask with nonstandard taper outer joint. The flask wasattached to a 12 mm tip diameter probe and the reaction mixture wassonicated at ambient temperature for the specified period at 50% power of theprocessor and 230W output in a 4 s pulse mode. At the end of the reactionperiod, TLC was checked and the flask was detached from the probe and thecontent was transferred into a beaker. The formed solid was filtered off andwashed thoroughly with cold ethanol (2 10 ml) to afford the Knoevenageladduct 3.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanoacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dandia, Anshu; Jain, Anuj K.; Laxkar, Ashok K.; Bhati, Dharmendra S.; Tetrahedron Letters; vol. 54; 24; (2013); p. 3180 – 3184;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts