1223434-15-8, name is Methyl 4-bromo-2-cyanobenzoate, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C9H6BrNO2
Methyl 4-bromo-2-cyanobenzoate (800.0 mg; 3.33 mmol; 1.00 eq.) was combined with titanium(IV) isopropoxide (1.10 mL; 3.67 mmol; 1.10 eq.) in dry diethyl ether (16 mL) under argon atmosphere and ethylmagnesium bromide (2.22 mL; 3 M solution in diethyl ether; 6.67 mmol; 2.00 eq.) was added at rt. After 2h stirring, the reaction was quenched with 1N HCI (2 mL) and extracted with DCM. The organic extract was washed with brine, dried over MgSO4 and concentrated under reduced pressure. The residue was recrystallized from a mixture of diethyl ether and n-heptane giving 5′-bromospiro[cyclopropane-1,3′-isoindoline]-1′-one (385.0 mg; 49 %).
The synthetic route of 1223434-15-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eng Bang Tiba; Ba Seu-ma-tin; Kon Tal-sil-bi-e; Ju Ni-en-jang—ru-i-seu; Ma Sa-reu-di-e-reu-keu-ri-seu-tin; Mon Tal-be-ti-keu-ri-seu-chan; Su Deu-an-ne; (111 pag.)KR2019/137803; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts