Electric Literature of 403-54-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 403-54-3 as follows.
General procedure: A mixture of nitriles (5 mmol), methyl ethers (6 mmol) and Fe(ClO4)3¡¤H2O (5%mol) was placed in a round bottom flask. Then the reaction mixture was heated at 100 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), 10 ml water was added into reaction system and extracted with ethyl acetate (3 ¡Á 20 ml). The organic layers were collected, combined, washed with water (3 ¡Á 20 ml), dried over anhydrous Na2SO4, and concentrated under vacuum. The pure products (1a-1k and 2a-2p) were obtained by directly passing through a silica gel (200-300 mesh) column using petroleum ether/ethyl acetate (10:1-5:1).
According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yin, Guibo; Yan, Bin; Chen, Junqing; Ji, Min; Journal of the Iranian Chemical Society; vol. 16; 6; (2019); p. 1355 – 1363;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts