Application of 621-03-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 621-03-4, name is 2-Cyano-N-phenylacetamide, This compound has unique chemical properties. The synthetic route is as follows.
Cyanoacetic acid (0.96 g, 11.1 mmol, 1 eq) was added to a mixture of PC15 (2.35 g, 11.1 mmol, 1 eq) in 200 mL of CH2C12, and the mixture refluxed for 30 minutes. After cooling, aniline (1.01 mL, 1.03 g, 11.1 mmol) was added and the solution was refluxed for 2hrs. The reaction mixture was allowed to cool to room temperature, and then concentrated to dryness at the rotary evaporator. A 50 mL portion of water was added and the suspension was filtered. The resulting solid was then washed with 25 mL of 1.0 N NaHC03 solution, 25 mL of water and then dried to afford the desired cyanoamide as a white amorphous solid (1.64 g, 92%). This solid was of sufficient purity to be used without further purification in the subsequent reaction. 1H NMR (400 MHz, acetone-d6) delta 9.58 (s, 1H), 7.62 (d, / = 8.4 Hz, 2H), 7.33 (t, / = 8.0 Hz, 2H), 7.11 (t, / = 7.2 Hz, 1H), 3.82 (s, 2H).A 0.9 g portion (12.8 mmol, 1.25 eq) of NH2OH HCl was added to Na2C03 (1.36 g, 12.8 mmol, 1.25 eq) dissolved in 5 mL of water, and the solution was diluted with 50 mL of methanol. The cyanoamide from the previous step (1.64 g, 10.2 mmol) was added and the mixture was refluxed for 2 hours. After cooling, the reaction mixture was concentrated in vacuo, and the resulting solid was mixed with a hot 3:1 mixture of ethyl acetate:hexane. The insoluble material was immediately removed by filtration, and the filtrate was concentrated to dryness at the rotary evaporator. The solid residue was purified by column chromatography (silica gel, ethyl acetate: methanol 20:1) and recrystallized to afford Example 1 as a white crystalline solid (0.67 g, 34%). 1H NMR (400 MHz, acetone-d6) delta 9.53 (s, 1H), 8.70 (s, 1H), 7.65-7.63 (m, 2H), 7.31-7.27 (m, 2H), 7.07-7.04 (m, 1H), 5.39 (s, 2H), 3.17 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N-phenylacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; THE JOHNS HOPKINS UNIVERSITY; CASERO, Robert, A.; BYTHEWAY, Ian; WOSTER, Patrick, M.; WO2012/34116; (2012); A2;,
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