Share a compound : 64248-62-0

Synthetic Route of 64248-62-0,Some common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, molecular formula is C7H3F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.6 mL (7.2 mmol) of trimethyl aluminum (2.0 M toluene solution) was dropwise added to a 10 mL of toluene containing 384 mg (7.17 mmol) of ammonium chloride at room temperature. After stirring for 1.5 hours, 1 g (7.1 mmol) of3,4-difluorobenzonitrile was added thereto and the resulting mixture was heated to EPO 85C for 9 hours. After completion of a reaction, the reaction solution was poured into100 mL of chloroform containing 200 g of silicagel and filtered off. The residue was washed with 200 mL of methanol and distillation was conducted to give 370 mg (2.36 mmol) of the title compound in a yield of 33%. [920] NMR: 1H-NMR(CD3OD) delta 7.87~7.82(1H, m), 7.72~7.7O(1H, m), 7.63~7.55(1H, m)[921] Mass(EI) 157(M++.)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4-Difluorobenzonitrile, its application will become more common.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2006/104356; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts