Adding a certain compound to certain chemical reactions, such as: 90433-20-8, name is 2-(3-Bromophenyl)-2-methylpropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90433-20-8, Recommanded Product: 2-(3-Bromophenyl)-2-methylpropanenitrile
General procedure: To a mixture of compound 5 (2.00 g, 12.3 mmol), X-Phos (0.292 g, 0.613 mmol), sodium tert-butoxide (2.94 g, 30.6 mmol) and tris(dibenzylidineacetone)dipalladium (0.224 g, 0.245 mmol) in 1,4-dioxane (25 mL) was added 4-bromoanisole (1.6 mL, 12.9 mmol) and heated to 100 C for 2 h. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and concentrated in vacuo. The residue was powdered from diethyl ether to give the title compound (2.02 g, 61%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Bromophenyl)-2-methylpropanenitrile, and friends who are interested can also refer to it.
Reference:
Article; Mochizuki, Michiyo; Kori, Masakuni; Kono, Mitsunori; Yano, Takahiko; Sako, Yuu; Tanaka, Maiko; Kanzaki, Naoyuki; Gyorkos, Albert C.; Corrette, Christopher P.; Aso, Kazuyoshi; Bioorganic and Medicinal Chemistry; vol. 24; 19; (2016); p. 4675 – 4691;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts