Some thienyl analogs of amidinomycin was written by Paul, Heinz;Migulla, Heinz. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1978.Name: 4-Nitrothiophene-2-carbonitrile This article mentions the following:
RCONHCH2CH2CN (I; R = 4-nitro-2-thienyl, 5-nitro-2-thienyl, 2-thienyl) were prepared by saponification of RCN, chlorination of RCO2H, and reaction of RCOCl with H2NCH2CH2CN. I [R = 4-(4-tosylamino)-2-thienyl, 4-amino-2-thienyl, 5-amino-2-thienyl, 4-isopropylamino-2-thienyl, 5-isoproipylamino-2-thienyl] were similarly prepared I were subjected to ethanolysis to give RCONHCH2CH2C(:NH)OEt, which were treated with NH3 to give amidines RCONHCH2CH2C(:NH)NH2. None of the compounds prepared had any antiviral activity. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Name: 4-Nitrothiophene-2-carbonitrile).
4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Name: 4-Nitrothiophene-2-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts