Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1194-02-1, name is 4-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-Fluorobenzonitrile
General procedure: To the solution of NaOH (5.93 g, 0.15 mol) in water (20 mL) and ethanol (120 mL), hydroxylamine hydrochloride (10.33 g, 0.15 mol) was added in one portion at room temperature. The resulting mixture was then stirred for 10 min, followed by the addition of 4-substituted cyanobenzene (1, 0.12 mol) and then heated to reflux for 4 h. After cooled to room temperature, the reaction mixture was evaporated in vacuo to remove ethanol. The obtained slurry was dissolved in ethyl acetate and filtered. The filtrate was collected, dried over anhydrous Na2SO4, and then concentrated to give corresponding compound 2, which was used in next step without any purification.
According to the analysis of related databases, 1194-02-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Dai, Hong; Chen, Jia; Li, Gang; Ge, Shushan; Shi, Yujun; Fang, Yuan; Ling, Yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 4; (2017); p. 950 – 953;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts