Electric Literature of 914637-31-3,Some common heterocyclic compound, 914637-31-3, name is 2-(3-Fluoro-5-methoxyphenyl)acetonitrile, molecular formula is C9H8FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-(3-fluoro-5-methoxyphenyl)acetonitrile (2.62 g, 16 mmol) in MeOH:H20 (1 :1; 15 mL), NaOH (1.28 g, 32 mmol) was added. Then the mixture was stirred at 65 C for 4 h. The mixture was cooled to room temperature, and 4M aqueous HCl solution was added until the pH was adjusted to 4~5. The mixture was filtered and the solid obtained was washed with H20 (2 x 5 mL) to give 2.33 g of 2-(3-fluoro-5-methoxyphenyl)acetic acid. H NMR (CDC13): delta 6.52-6.62 (m, 3H), 3.78 (s, 3H), 3.59 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(3-Fluoro-5-methoxyphenyl)acetonitrile, its application will become more common.
Reference:
Patent; ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.; WO2011/156518; (2011); A2;,
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