Highly enantioselective bioreduction of prochiral ketones by stem and germinated plant of Brassica oleracea variety italica was written by Mohammadi, Mehdi;Yousefi, Maryam;Habibi, Zohreh. And the article was included in Biocatalysis and Biotransformation in 2011.Category: nitriles-buliding-blocks This article mentions the following:
An eco-friendly and environmentally benign asym. reduction of a broad range of prochiral ketones employing Brassica oleracea variety italica (stems and germinated plant) as a novel biocatalyst was developed. It was found that B. oleracea variety italica could be used effectively for enantioselective bioreduction in aqueous medium with moderate to excellent chem. yield and enantiomeric excess (ee). This process is more efficient and generates less waste than conventional chem. reagents or microorganisms. Both R- and S-configurations were obtained by these asym. reactions. The best ee were achieved for pyridine derivatives (92-99%). The ee in germinated plant reactions were significantly higher than those of stem reactions. The low cost and the easy availability of these biocatalysts suggest their possible use for large scale preparations of important chiral alcs. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Category: nitriles-buliding-blocks).
(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts