Synthesis, reactions, and antimicrobial activity of some fused thieno[2,3-d]yrimidine derivatives was written by Prabhu, Pradnya J.;Khombare, Rajiv T.;Kadam, Mangesh D.. And the article was included in International Journal of Chemistry (Mumbai, India) in 2013.Safety of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate This article mentions the following:
Novel thieno[2,3-d]pyrimidines, 4-imino-pyrimidin-3-ylamine and pyrimidon-4-ylhydrazine derivatives were prepared starting from ethyl-5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate and 5-amino-4-cyano-3-methyl-thiophene-2-carboxylic acid Et ester. The antimicrobial evaluation of the synthesized compounds showed that many of them revealed promising antimicrobial activity. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Safety of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Safety of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts