Formal Substitution of Bromocyclopropanes with Nitrogen Nucleophiles was written by Banning, Joseph E.;Gentillon, Jacob;Ryabchuk, Pavel G.;Prosser, Anthony R.;Rogers, Andrew;Edwards, Andrew;Holtzen, Andrew;Babkov, Ivan A.;Rubina, Marina;Rubin, Michael. And the article was included in Journal of Organic Chemistry in 2013.Recommanded Product: 10282-32-3 This article mentions the following:
A highly chemo- and diastereoselective protocol toward amino-substituted donor-acceptor cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is described. A wide range of N-nucleophiles, including carboxamides, sulfonamides, azoles, and anilines, can be efficiently employed in this transformation, providing expeditious access to stereochem. defined and densely functionalized cyclopropylamine derivatives In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Recommanded Product: 10282-32-3).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 10282-32-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts