Solubility and solution thermodynamics of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate in nine organic solvents at evaluated temperatures was written by Han, Shuo;Meng, Long;Du, Cunbin;Xu, Jian;Cheng, Chao;Wang, Jian;Zhao, Hongkun. And the article was included in Journal of Chemical Thermodynamics in 2016.HPLC of Formula: 58168-20-0 This article mentions the following:
Knowledge of solubility for Et 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate (ACET) in different solvents is essential for its purification and further theor. studies. In this paper, the solubility of ACET in selected pure solvents, including methanol, ethanol, 1-butanol, n-propanol, isopropanol, toluene, Et acetate, acetonitrile and acetone were acquired by a high-performance liquid chromatog. (HPLC) at T = (273.15, 278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15 and 318.15) K under pressure of 0.1 MPa. Generally, they obeyed the following order from high to low in different solvents: acetone > Et acetate > acetonitrile > methanol > ethanol > isopropanol > n-propanol > 1-butanol > toluene. The obtained solubility data of ACET in selected solvents were correlated by the van’t Hoff equation, modified Apelblat equation, λh equation, Wilson model and NRTL model. The correlated values of the five equations agreed well with the exptl. values and the Wilson model gives better correlation results than other models. Furthermore, the standard dissolution enthalpy and excess enthalpy for dissolution process of ACET were calculated from the exptl. solubility by using the van’t Hoff equation. The solubility values of ACET in different solvents and thermodn. relations would be invoked as fundamental data and models regarding the crystallization process of ACET. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0HPLC of Formula: 58168-20-0).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 58168-20-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts