Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20099-89-2, name is 4-(2-Bromoacetyl)benzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C9H6BrNO
2-Aminopyridine (1.88 g) and 2-bromo-4′-cyanoacetophenone (4.48 g) were dissolved in ethanol (40 mL), and sodium hydrogencarbonate (1.85 g) was added to the solution, followed by refluxing for 10 hours. Water was added to the reaction mixture, and the mixture was extracted with chloroform, followed by drying over magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to flash column chromatography. Fractions eluted by dichloromethane-methanol (100 : 1) were concentrated under reduced pressure, and the solid was recovered through filtration by use of diethyl ether, to thereby yield 4-imidazo[1,2-a]pyridin-2-ylbenzonitrile (3.82 g). 1H-NMR(400MHz,DMSO-d6)delta:6.94(1H,tt,J=1.0,6.8Hz), 7.30(1H,ddt,J=1.0,6.8,9.0Hz),7.62(1H,d,J=9.0Hz), 7.90(2H,d,J=8.5Hz),8.16(2H,d,J=8.5Hz), 8.56(1H,ddd,J=1.0,2.0,6.8Hz),8.60(1H,s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Fujifilm RI Pharma Co., Ltd.; Daiichi Sankyo Company, Limited; EP1956013; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts