Yang, Bowen published the artcileDiscovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors, HPLC of Formula: 1036991-35-1, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127749, database is CAplus and MEDLINE.
In an inhouse screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC50 values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.
Bioorganic & Medicinal Chemistry Letters published new progress about 1036991-35-1. 1036991-35-1 belongs to nitriles-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, and the molecular formula is C14H12N2S, HPLC of Formula: 1036991-35-1.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts