Ieda, Naoya published the artcileDevelopment of photoredox-reaction-driven NO-releasing reagents and application for photomanipulation of vasodilation, Application In Synthesis of 26187-28-0, the publication is Yuki Gosei Kagaku Kyokaishi (2020), 78(11), 1048-1057, database is CAplus.
Nitric oxide (NO) is a signaling mol. that mediates vasodilation, neurotransmission, and immune response. Due to its instability in biol. environments, NO-releasing small-mol. compounds have been developed for biol. experiments and also as therapeutic reagents for vascular diseases. Although photocontrollable NO releasers are very useful chem. tools because of their precise operability in response to light irradiation, their biol. applications have been limited, mainly because they require UV light irradiation or contain metal ions with the potential to cause cytotoxicity. In order to overcome these problems, our group has developed visible-light-responsive NO releasers based on photoreodox reaction. These compounds are composed of two moieties, an NO-releasing moiety and a light-harvesting antenna moiety. After photoirradiation, photoinduced electron transfer from the NO releasing moiety to the antenna takes place, followed by NO release. Based on this system, we developed a blue-light-controllable NO releaser and a yellowish-green-light-controllable one, which are applicable for cellular and ex vivo experiments This account focuses on recent developments in photoredox-driven NO releasers and their applications for spatiotemporally controlled NO release in cells and ex vivo.
Yuki Gosei Kagaku Kyokaishi published new progress about 26187-28-0. 26187-28-0 belongs to nitriles-buliding-blocks, auxiliary class Pyrrole,Nitrile, name is 2,4-Dimethyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C7H8N2, Application In Synthesis of 26187-28-0.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts