Adding a certain compound to certain chemical reactions, such as: 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939-79-7, Formula: C8H6N2O2
A mixture of 3-nitro-p-tolunitrile (9.30 g, 57.4 mmol, 1 equiv) and 10% Pd/C (4.00 g,3.76 mmol, 0.066 equiv) in ethanol (100 mL) was stirred under a hydrogen balloon at 23 C for 20 h. The catalyst was filtered onto a pad a celite and washed with EtOAc (300 mL). The filtrate was concentrated to give 3-amino-4-methylbenzonitrile (1-2) as an off-white solid. 1H NMR (300 MHz, CDCl3) delta 7.10 (d, 1H, J = 7.6 Hz), 6.98 (dd, 1H, J = 7.9, 1.5 Hz), 6.89 (d, 1H, J = 1.5 Hz), 3.78 (br s, 2H), 2.20 (s, 3H). LRMS m/z (M+H + CH3CN) 174.2 found, 174.1 required.
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Reference:
Patent; MERCK & CO., INC.; WO2006/86255; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts