Kodama, Koichi published the artcileCyanative self-condensation of aromatic aldehydes promoted by VO(OiPr)3-Lewis base as a cooperative catalyst, Application of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, the publication is Organic & Biomolecular Chemistry (2012), 10(47), 9440-9446, database is CAplus and MEDLINE.
In the presence of oxovanadium triisopropoxide and an amine such as 4-dimethylaminopyridine, aromatic aldehydes underwent self-condensation with trimethylsilyl cyanide under an oxygen atm. in acetonitrile to give α-cyanobenzyl benzoates RCH(CN)OCOR (R = Ph, 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 4-BrC6H4, 4-MeC6H4, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4) (I) in 28-81% conversions and with 93:7-99:1 chemoselectivity for the cyanobenzyl benzoates over the corresponding cyanohydrins. A variety of Lewis base additives acted as cocatalysts for the reaction; reactions performed under nitrogen gave similar conversions but reduced selectivities for cyanobenzyl benzoates. The choice of solvent also altered chemoselectivity significantly. When (R)-PhCHMeNMe2 was used as a Lewis basic cocatalyst, (S)-I (R = 4-ClC6H4) was obtained in 61% conversion, 99:1 chemoselectivity, and 8% ee.
Organic & Biomolecular Chemistry published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Application of 2-(2-Chlorophenyl)-2-hydroxyacetonitrile.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts