Some scientific research about 403-54-3

Synthetic Route of 403-54-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 403-54-3 as follows.

4.12 mL (8.24 mmol) of trimethyl aluminum (2.0 M toluene solution) was added to a 10 mL of toluene containing 441 mg (8.24 mmol) of ammonium chloride at room temperature. After stirring for 1.5 hours, 2 g (28.9 mmol) of isobutyronitrile was added EPO thereto and the resulting mixture was heated to 85C for 9 hours. After completion of a reaction, the reaction solution was poured into 200 mL of chloroform containing 200 g of silicagel and filtered off. The residue was washed with 100 mL of methanol and distillation was conducted to give 731 mg (5.29 mmol) of the title compound in a yield of 64%.[936] NMR: 1H-NMR(CD OD) delta 7.71~7.44(4H, m)[937] Mass(EI) 139(M++.)

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2006/104356; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts