Teyateeti, Ajalaya published the artcileSurvival outcomes for yttrium-90 transarterial radioembolization with and without sorafenib for unresectable hepatocellular carcinoma patients, Application of Phthalonitrile, the main research area is 90Y; TheraSphere; adverse events; prognostic factors; selective internal radiation therapy.
Purpose: To assess the overall survival (OS) and progression-free survival (PFS) of unresectable hepatocellular carcinoma (HCC) patients undergoing yttrium-90 glass-microsphere transarterial radioembolization (TARE) with and without concurrent sorafenib. Methods: OS and PFS were analyzed in 55 patients with an intrahepatic tumor (IHT) â?0% without advanced or aggressive disease features (ADFs), which was referred to presence of infitrative/ill-defied HCC, macrovascular invasion, or extrahepatic disease treated with only TARE (TARE_alone) and in 74 patients with IHT â?0% with ADFs or IHT >50% treated with TARE and sorafenib (TARE_sorafenib). Prognostic factors for OS and PFS were identified using univariate and multivariate analyses. Results: Median OS and PFS of TARE_alone patients were 21.6 (95% CI 6.1-37.1) and 9.1 (95% CI 5.2-13.0) months, resp., and for TARE_sorafenib patients 12.4 (95% CI 9.1-15.6) and 5.1 (95% CI 2.6-7.5) months, resp. Better OS was associated with serum AFP <400 (HR 0.27, p=0.02) in TARE_alone, and IHT â?0% (HR 0.39, p=0.004) and AFP <400 (HR 0.5, p=0.027) in TARE_sorafenib. Unilobar involvement (HR 0.43, p=0.029) and AFP <400 ng/mL (HR 0.52, p=0.015) correlated with better PFS in TARE_alone and TARE_sorafenib, resp. Adverse events (AEs) were more frequent in TARE_sorafenib than TARE_alone (92.4 vs 80.3%), but only 9.3% were grade 3 or higher AEs. Conclusion: TARE_alone provided the most prominent survival benefit in IHT â?0%- without ADF patients who had unilobar HCC and serum AFP <400 ng/mL. TARE and sorafenib yielded the best outcomes in patients with IHT â?0% and serum AFP <400 ng/mL, with some addnl. grade 1-2 AEs compared to TARE only. Journal of Hepatocellular Carcinoma published new progress about 90Y; TheraSphere; adverse events; prognostic factors; selective internal radiation therapy. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts