Rani, Anu published the artcile1H-1,2,3-triazole grafted tacrine-chalcone conjugates as potential cholinesterase inhibitors with the evaluation of their behavioral tests and oxidative stress in mice brain cells, SDS of cas: 1885-29-6, the main research area is triazole grafted tacrine chalcone conjugate cholinesterase inhibitor oxidative stress; 1H-1,2,3-triazole-tacrine-chalcone; Alzheimer’s disease; An Acetylcholinesterase inhibitor; Behavioral models; Butyrylcholinesterase inhibition; Molecular docking; Oxidative stress parameters.
The present paper explicates the synthesis of 1H-1,2,3-triazole tethered tacrine-chalcone conjugates and evaluation of their AChE and BuChE inhibitory activity. In-vitro AChE inhibition assay revealed three compounds, 9h, 9i, and 11f, being more potent than the standard drug tacrine and further evaluated against butyrylcholinesterase. The present study was extended to investigate the anti-amnestic effect of promising compounds on scopolamine-induced behavioral and neurochem. changes in mice. Inclined plane model and Elevated plus-maze model were performed to assess general limb motor activity and anxiety-like behavior, resp., in mice pre-treated with scopolamine. Oxidative stress parameters reduced glutathione contents (GSH) and lipid peroxidation products (TBARS) in the brain homogenates as estimated using ex-vivo studies. Furthermore, mol. docking studies were performed for the potent compounds to decipher the mechanism of observed activities.
Bioorganic Chemistry published new progress about Anxiety. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts