Wimmer, Eric published the artcileAn autonomous self-optimizing flow machine for the synthesis of pyridine-oxazoline (PyOX) ligands, Recommanded Product: Picolinonitrile, the main research area is pyridine oxazoline ligand self optimizing flow machine.
Pyridine-oxazoline-type ligands (PyOX) are an important class of chiral ligands for metal-catalyzed asym. transformations. Herein we describe an efficient and reliable flow route which is amenable for the synthesis of PyOX ligands at a scale of hundreds of milligrams per h. Optimal flow conditions were rapidly identified through the assistance of an inhouse built autonomous self-optimizing system integrating a custom-made optimization algorithm derived from the Nelder-Mead and golden section search methods. The preparation of a small library of representative PyOX ligands highlights the practical application of this flow route which should be of primary interest for synthetic chemists developing metal-catalyzed asym. transformations.
Reaction Chemistry & Engineering published new progress about Algorithm. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts