139152-08-2, name is 4,5-Dichlorophthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 139152-08-2
4,5-Dichlorophthalonitrile 1 (1.00 g, 5.08 mmol) and 7-hydroxy-4-(4-methoxyphenyl)-8-methylcoumarin 2 (5.73 g, 20.32 mmol) were dissolved in anhydrous dimethylformamide (DMF) (30 mL) under N2 atmosphere. After stirring for 10 min, finely ground anhydrous K2CO3 (3.50 g, 25.37 mmol) was added by stirring. The reaction mixture was stirred at 50 C for 10 days under N2 atmosphere. Then the mixture was poured in 250 ml cold aqueous solution of 5% HCl. The formed precipitate was filtered off and washed with water. After drying in vacuum at 50 C, the crude product was purified by column chromatography with silica gel eluting with DCM. Firstly, compound 3 and then compound 4 were obtained purely by using DCM and chloroform as eluting solvents, respectively.
Statistics shows that 139152-08-2 is playing an increasingly important role. we look forward to future research findings about 4,5-Dichlorophthalonitrile.
Reference:
Article; Altun, Selcuk; Oezkaya, Ali Riza; Bulut, Mustafa; Polyhedron; vol. 48; 1; (2012); p. 31 – 42;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts