Solid-Phase synthesis of diamine and polyamine amino acid derivatives as HIV-1 tat-TAR binding inhibitors was written by Jimenez Bueno, G.;Klimkait, T.;Gilbert, I. H.;Simons, C.. And the article was included in Bioorganic & Medicinal Chemistry in 2003.Formula: C20H34N4O4 The following contents are mentioned in the article:
A series of diamine and polyamine derivatives, either free amines or salts (HCl or TFA), of aspartic and glutamic acid were prepared in excellent yields using Rink Amide solid-phase synthesis. The asparagine and glutamine derivatives were all evaluated for their ability to inhibit Tat-TAR binding using a FIGS (fusion induced gene stimulating) cellular assay, with the polyamine derivatives exhibiting the most promising binding activity. This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8Formula: C20H34N4O4).
Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Formula: C20H34N4O4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts