Aydin, Ali published the artcileIn-Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM, Application In Synthesis of 1885-29-6, the main research area is brominated indenoqinoline amine anticancer antibacterial activity mol docking MCDM.
The present study describes mono substituted indeno[1,2-b]quinolines (3 a-c and 5) have much more antiproliferative potentials than pos. controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1-29.6 μg/mL) and show similar cytotoxicity (14.3% to 19.8%) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a-c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μ g/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103-1.1×105 M-1. The anticancer and antibacterial properties of compounds were confirmed with the mol. docking simulation for their pharmacokinetic. As a result, the preliminary exptl. data and a multi-criteria decision-making methodol. (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacol. properties. parameters and their interaction with related cells at the mol. level.
ChemistrySelect published new progress about Antibacterial agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts