Reference of 1897-52-5, These common heterocyclic compound, 1897-52-5, name is 2,6-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 0.11 mol (7.65 g) to a 250 mL reaction flask.Hydroxylamine hydrochloride,50g of ethyl acetate as a solvent,Then add 0.11 mol of triethylamine (11.11g)And 0.1 mol (13.9 g) of 2,6-difluorobenzonitrile,Stir,Heating at 80 C for 4 h,TLC tracking reaction is complete,cool down,Filtering,The filtrate was evaporated to remove EA.cool down,Obtained white solid compound II 14.62g,The yield was 85%.
Statistics shows that 2,6-Difluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 1897-52-5.
Reference:
Patent; Qingdao University of Science and Technology; Xu Liangzhong; Peng Zhuang; Cui Huanqi; Sun Jianxin; Wang Minghui; (8 pag.)CN109320506; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts