Li, Bryan’s team published research in Organic Process Research & Development in 2007-12-31 | CAS: 87150-13-8

Organic Process Research & Development published new progress about Bromination, regioselective. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Li, Bryan published the artcileSyntheses of 4,5-Disubstituted Oxazoles via Regioselective C-4 Bromination, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is regioselective bromination oxazole derivative; Suzuki coupling bromooxazole phenylboronic acid; aryloxazole preparation; triethylamine removal iron palladium Suzuki coupling reaction.

A scaleable and highly regioselective C-4 bromination of 5-substituted oxazoles is described. The use of DMF as solvent played a critical role in significantly improving the C-4/C-2 bromination ratio. The resulting 4-bromooxazoles were shown to be good Suzuki-Miyaura coupling partners with arylboronic acids. Furthermore, a simple and convenient method that employs triethylamine efficiently purged residual levels of palladium and iron to less than 10 ppm.

Organic Process Research & Development published new progress about Bromination, regioselective. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts