Reference of 127946-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
The carboxylic acid 5A (195 mg, 0.5 mmol), 1-aminocyclopropanecarbonitrile hydrochloride (65.2 mg, 550 muiotaetaomicron), HATU (380 mg, 1.00 mmol) and ethyldiisopropyl amine (262 mu, 1.5 mmol) were dissolved in acetonitrile (10 mL) and stirred at room temperature over night. The reaction was concentrated under reduced pressure. The residue was diluted with 5% aquous sodium carbonate solution and extracted twice with ethyl acetate. The combined organic layers were washed withlM aqueous hydrogen chloride solution and with saturated aqueous sodium chloride solution, dried over Na2S04, filtered and concentrated under reduced pressure to yield (2S,4R)-iert-butyl 4-(2- chlorophenylsulfonyl)-2-( 1 -cyanocyclopropylcarbamoyl)-pyrrolidine- 1 -carboxylate 6H as a yellow oil (66 %). MS ISP (m/e): 354.2 (100) [(M-BOC+H)]+, 398.1 (25) [(M- Isobutylene+H)]+, 454.1 (12) [(M+H)]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BANNER, David; HAAP, Wolfgang; LUEBBERS, Thomas; PETERS, Jens-Uwe; WO2013/120921; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts