Martin-Torres, Inmaculada published the artcileEnantioselective Alkoxycyclization of 1,6-Enynes with Gold(I)-Cavitands: Total Synthesis of Mafaicheenamine C, Formula: C8H4N2, the main research area is gold cavitand complex preparation catalyst enantioselective alkoxycyclization enyne mechanism; mafaicheenamine C enantioselective synthesis absolute configuration; alkoxycyclization; asymmetric synthesis; gold(I) cavitands; natural product synthesis.
Chiral gold(I)-cavitand complexes have been developed for the enantioselective alkoxycyclization of 1,6-enynes. This enantioselective cyclization has been applied for the first total synthesis of carbazole alkaloid (+)-mafaicheenamine C (I) and its enantiomer, establishing its configuration as R. The cavity effect was also evaluated in the cycloisomerization of dienynes. A combination of experiments and theor. studies demonstrates that the cavity of the gold(I) complexes forces the enynes to adopt constrained conformations, which results in the high observed regio- and stereoselectivities.
Angewandte Chemie, International Edition published new progress about Absolute configuration (of mafaicheenamine C). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts