Steric hindrance-enforced distortion as a general strategy for the design of fluorescence “turn-on” cyanide probes was written by Chen, Bin;Ding, Yubin;Li, Xin;Zhu, Weihong;Hill, Jonathan P.;Ariga, Katsuhiko;Xie, Yongshu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Category: nitriles-buliding-blocks This article mentions the following:
For the rational design of fluorescence “turn-on” cyanide probes, a general strategy is developed by introducing a dicyanovinyl group at the sterically demanding position of a large 锜?framework. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Category: nitriles-buliding-blocks).
2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. The R-C-N bond angle in and nitrile is 180鎺?which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two 锜? bond in the triple bond. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts