Combinatorial synthesis of chemical building blocks 1. Azomethines was written by Ryabukhin, Sergey V.;Panov, Dmitriy M.;Plaskon, Andrey S.;Chuprina, Alexander;Pipko, Sergey E.;Tolmachev, Andrey A.;Shivanyuk, Alexander N.. And the article was included in Molecular Diversity in 2012.Synthetic Route of C8H8N2S This article mentions the following:
128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me3SiCl as promoter and water scavenger in 58-98% yield. Et3N was added to reaction mixtures before precipitating the product with H2O to prevent acid catalyzed hydrolysis of the C:N bond. The scope and limitation of the method are discussed. High yields and a simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were intermediates in a one-pot combinatorial synthesis of amines and amides. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Synthetic Route of C8H8N2S).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115閳?25 ppm whereas in isonitriles the shifts are around 155閳?65 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Synthetic Route of C8H8N2S
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts