Amide-Directed C-H Sodiation by a Sodium Hydride/Iodide Composite was written by Huang, Yinhua;Chan, Guo Hao;Chiba, Shunsuke. And the article was included in Angewandte Chemie, International Edition in 2017.Product Details of 5351-07-5 This article mentions the following:
A new protocol for amide-directed ortho and lateral C-H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5Product Details of 5351-07-5).
2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Product Details of 5351-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts