Synthesis of strontium ranelate, an antiosteoporosis drug was written by Ding, Xiangyu;Jiang, Ye;Jia, Xiangman;Liu, Fenghua. And the article was included in Zhongguo Yaoxue Zazhi (Beijing, China) in 2008.SDS of cas: 58168-20-0 This article mentions the following:
The synthesis route of strontium ranelate, an antiosteoporosis drug was studied. Strontium ranelate was synthesized from citric acid via decarboxylation, esterification, cyclization, alkylation, hydrolysis and salification. The structure of strontium ranelate was confirmed by IR, 1H-NMR, 13C-NMR and the total yield was 42.6% approx. The synthesis route was simple, low cost and could be used in industry. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0SDS of cas: 58168-20-0).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. SDS of cas: 58168-20-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts