Reactivity of 2-aminothiophenes. Application to synthesis of thieno[2,3-b]pyrroles was written by Wierzbicki, Michel;Cagniant, Denise;Cagniant, Paul. And the article was included in Bulletin de la Societe Chimique de France in 1975.Name: Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate This article mentions the following:
Thienopyrroles I (R = H, Ac; R1 = OH, NH2; R2 = CH2CO2Et, Me; R3 = CO2Et, Ac) were prepared by treating the thiophenes II (R4 = H; R5 = CO2Et, CN) with BrCH2CO2Et and Dieckmann reaction of II (R4 = CH2CO2Et). I (R1 = OH) were alkylated with BrCH2CO2Et or acetylated. I (R2 = NH2) were acetylated and diazotized. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Name: Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate).
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Name: Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts