Studies on aromatic nitro compounds. V. A simple one-pot preparation of o-aminoaroylnitriles from some aromatic nitro compounds was written by Tomioka, Yukihiko;Ohkubo, Kimiko;Yamazaki, Motoyoshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1985.Synthetic Route of C8H5F3N2 This article mentions the following:
The reactions of aromatic nitro compounds I, II (R = H, R1 = NO2), and III (R, R1 = same, R2 = CF3, MeCO, PhCO, R3 = H ; R2 = R3 = CF3) with Et cyanoacetate and KOH in DMF followed by hydrolysis of the reaction mixture with HCl or NaOH gave the corresponding o-aminoaroylnitriles I–III (R = CN, R1 = NH2). Acetylation-cyclization reactions of the products were carried out. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Synthetic Route of C8H5F3N2).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Synthetic Route of C8H5F3N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts