Structure-taste relationship of perillartine and nitro- and cyanoaniline derivatives was written by Iwamura, Hajime. And the article was included in Journal of Medicinal Chemistry in 1980.SDS of cas: 60979-25-1 This article mentions the following:
The relation between structure and taste potency of perillartine (I) and its analogs was investigated quant. by physicochem. parameters and regression anal. The results indicated that the hydrophobicity estimated from the octanol/water partition coefficient and the mol. widths from the bond axis connecting the oxime C atom and alicyclic ring are important, regardless of whether the taste is sweet or bitter, so far as taste potency is concerned. The structure-activity relation for the sweet/bitter ratio was not established quant., but the mol. width and thickness and the position-specific electronic effect appeared to delineate the ratio qual.; i.e., in principle, the wider and(or) the thicker the mol., the more bitter the taste. The quant. structure-activity relation of 5-nitro- and 5-cyanoaniline sweetener was formulated to show the nonsignificance of hydrophobicity within the compounds investigated but the importance of steric dimensions in determining the activity. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1SDS of cas: 60979-25-1).
3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.SDS of cas: 60979-25-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts