Gewald reaction catalyzed by KF/nano-γ-Al2O3 under microwave irradiation was written by Hong, Zhi;Li, Xu-yao;Chen, Can-li;Chen, Guang;Wang, Han-qing;Lu, Chen-chen. And the article was included in Huaxue Shiji in 2015.HPLC of Formula: 70291-62-2 This article mentions the following:
2-Aminothiophenes were synthesized by three components Gewald reaction using KF/nano-γ-Al2O3 as the base catalyst with microwave irradiation method. The effects of different reaction conditions on yield were investigated. This method has advantages of using cheap and high-efficient catalyst, simple purification, short reaction time and high product yield. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2HPLC of Formula: 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts