Ethylene diamine grafted nanoporous UiO-66 as an efficient basic catalyst in the multi-component synthesis of 2-aminothiophenes was written by Erfaninia, N.;Tayebee, R.;Dusek, M.;Amini, M. M.. And the article was included in Applied Organometallic Chemistry in 2018.Application of 70291-62-2 This article mentions the following:
This study demonstrates ED-UiO-66 as a novel and effective solid nanoporous basic catalyst prepared through the amine grafting onto the pores of UiO-66. The manufactured nanoparticles were identified by FT-IR, XRD, TGA, FESEM, TEM, CHN and BET and the characterization results certified formation of a single phase nanoporous substance with the medium grain size less than 90 nm. The synthesized material was employed as an efficient catalyst for the preparation of 2-aminothiophenes I [R = 4,5-(-CH2-)5, 5-CH3, 5-C6H5] through the Gewald method. This thermochem. stable nanocatalyst was environmentally safe, reusable and economic. Therefore, this methodol. can be simply extended for industrial goals. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Application of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Application of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts