A efficient protocol for the synthesis of thioamides in [DBUH][OAc] at room temperature was written by Cao, Xian-Ting;Qiao, Li;Zheng, Hui;Yang, Hui-Yong;Zhang, Peng-Fei. And the article was included in RSC Advances in 2018.HPLC of Formula: 63968-85-4 This article mentions the following:
A novel, simple and eco-friendly method to synthesize thioamides from aryl nitriles and sodium sulfide (Na2S·9H2O) catalyzed by 1,8-diazabicyclo[5,4,0]undec-7-enium acetate ([DBUH][OAc]) ionic liquid (IL) at room temperature was developed. In this reaction, readily available inorganic salt (Na2S·9H2O) served as the sulfur source and various functional groups of aryl nitriles were well tolerated at room temperature In addition, the products were easily separated from the IL which could be reused at least five times without considerable loss of its activity and applied in the green, concise synthesis of ethionamide. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4HPLC of Formula: 63968-85-4).
2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.HPLC of Formula: 63968-85-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts