Bhat, Radhika et al. published their research in Russian Journal of Organic Chemistry in 2021 | CAS: 60025-09-4

4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Computed Properties of C5H3ClN4

Synthesis, Characterization, Antimicrobial Activity Screening, and Molecular Docking Study of Pyrimidine Carbonitrile Derivatives was written by Bhat, Radhika;Begum, Noor Shahina. And the article was included in Russian Journal of Organic Chemistry in 2021.Computed Properties of C5H3ClN4 This article mentions the following:

The synthesis of pyrimidine carbonitrile derivatives I [R = 1-piperidyl, 2-phenylethylamino, 2-(1H-indol-3-ylmethylene)hydrazino, etc.] was described. The compounds I were characterized by FT-IR and 1H and 13C- NMR spectroscopy and mass spectrometry. All the compounds I were evaluated for in-vitro antimicrobial activity against different bacterial and fungal strains. The min. inhibitory concentrations (MICs) of all the compounds I were validated. Compounds I [R = 2-[(3,4-dimethoxyphenyl)methylene]hydrazino, 1-piperidyl], which had the lowest MIC values were selected for cell leakage anal. and bacterial growth curve study. It was found that both the compounds I [R = 2-[(3,4-dimethoxyphenyl)methylene]hydrazino, 1-piperidyl] have potential to induce bacterial cell membrane rupture and disintegration. Field emission scanning electron microscopic anal. confirmed the effect of the selected compounds on the morphol. of both Gram-pos. (S. aureus) and Gram-neg. (E. coli) bacteria. The mechanism of interaction between the drug and the target protein of S. aureus and E. coli was studied by mol. docking. In the experiment, the researchers used many compounds, for example, 4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4Computed Properties of C5H3ClN4).

4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Computed Properties of C5H3ClN4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts