Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases was written by Thinnes, C. C.;Tumber, A.;Yapp, C.;Scozzafava, G.;Yeh, T.;Chan, M. C.;Tran, T. A.;Hsu, K.;Tarhonskaya, H.;Walport, L. J.;Wilkins, S. E.;Martinez, E. D.;Muller, S.;Pugh, C. W.;Ratcliffe, P. J.;Brennan, P. E.;Kawamura, A.;Schofield, C. J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Quality Control of 3-Methylthiophene-2-carbonitrile This article mentions the following:
There is interest in developing potent, selective, and cell-permeable inhibitors of human ferrous iron and 2-oxoglutarate (2OG) oxygenases for use in functional and target validation studies. The 3-component Betti reaction enables efficient one-step C-7 functionalization of modified 8-hydroxyquinolines (8HQs) to produce cell-active inhibitors of KDM4 histone demethylases and other 2OG oxygenases; the work exemplifies how a template-based metallo-enzyme inhibitor approach can be used to give biol. active compounds In the experiment, the researchers used many compounds, for example, 3-Methylthiophene-2-carbonitrile (cas: 55406-13-8Quality Control of 3-Methylthiophene-2-carbonitrile).
3-Methylthiophene-2-carbonitrile (cas: 55406-13-8) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Quality Control of 3-Methylthiophene-2-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts