Calcined Mg-Al hydrotalcite as a heterogeneous base catalyst for Gewald aminothiophene synthesis was written by Rajagopal, R.;Jyothi, T. M.;Daniel, Thomas;Srinivasan, K. V.;Rao, B. S.. And the article was included in Synthetic Communications in 2001.COA of Formula: C8H8N2S This article mentions the following:
Calcined Mg-Al hydrotalcite (Mg/Al=4) has been conveniently employed as a heterogeneous base catalyst in the synthesis of 2-amino-3-cyanothiophenes adopting a one pot Gewald aminothiophene methodol. The compounds thus prepared included 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile, 2-amino-3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene and 2-amino-4,5-dimethyl-3-thiophenecarbonitrile. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2COA of Formula: C8H8N2S).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.COA of Formula: C8H8N2S
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts