Highly selective chemodosimeter for cyanide based on a doubly activated Michael acceptor type of coumarin thiazole fluorophore was written by Park, Seokan;Kim, Hae-Jo. And the article was included in Sensors and Actuators, B: Chemical in 2012.Recommanded Product: 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile This article mentions the following:
A doubly activated Michael acceptor type of coumarin thiazole fluorophore (1) was prepared and applied for the detection of cyanide ions in aqueous solution The chemodosimeter exhibited a highly selective and sensitive response to cyanide over other various anions through the Michael addition of cyanide to 1. Upon the addition of cyanide ions, the apparent color and fluorescence changes of 1 were observable with a detection limit of 2.3 μM of the cyanide anions in aqueous solution In the experiment, the researchers used many compounds, for example, 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6Recommanded Product: 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile).
7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Recommanded Product: 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts