Reactions of N-aminopyridinium derivatives. XII. Nucleophilic reactions of N-aminopyridinium derivatives was written by Ohsawa, Akio;Hirobe, Masaaki;Okamoto, Toshihiko. And the article was included in Yakugaku Zasshi in 1972.Synthetic Route of C7H6N2O This article mentions the following:
Derivatives of N-aminopyridine were synthesized and these derivatives underwent reaction with nucleophilic reagents. Progress of this reaction depended on the activity of the reagents as a nucleophilic species, substituent effect of the substrate, and reaction conditions. Electron-withdrawing nature of the substituent on the amino group determines the activity of the substrate while that of the substituent on ring C determines the orientation of the reaction, the greater the electron-withdrawing nature of ring C the greater the orientation towards the 2-position. The reaction results in addition and (or) substitution reaction and the reaction can be explained without inconsistency by assuming the progress of this reaction in 2 steps of addition and liberation even when only a substitution product is obtained. Depending on whether the addition step is reversible or irreversible, each step will be controlled either by thermokinetics or by chem. kinetics, and orientation towards the 4- or 2-position will be determined by which of these forces would be stronger. In the experiment, the researchers used many compounds, for example, 4-methoxypicolinonitrile (cas: 36057-44-0Synthetic Route of C7H6N2O).
4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Synthetic Route of C7H6N2O
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts