Synthesis and antimicrobial evaluation of new 4-{[(aryl)methylene]amino}-2-methyl-5,6-substituted thieno[2,3-d]pyrimidines was written by Naresh, K.;Rajeshwar, Y.;Jayaveera, K. N.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2014.Application of 70291-62-2 This article mentions the following:
A new series of 4-{[(aryl)methylene]amino}-2-methyl-5,6-substituted thieno[2,3-d]pyrimidines I (R1R2 = (CH2)3, (CH2)5; Ar = C6H5, 4-ClC6H4, 4-BrC6H4, 3-indolyl, etc.) was synthesized by the condensation of 4-amino-2,5,6-substituted theino[2,3-d]pyrimidines II with nine aromatic aldehydes. The compounds were further evaluated for the antibacterial and antifungal activity employing disk diffusion method. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Application of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Application of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts