The biological action of malononitriles. I. The effect of substituted malononitriles on the growth of transplanted tumors in mice was written by Gal, Emery M.;Fung, Fung-Haan;Greenberg, David M.. And the article was included in Cancer Research in 1952.Category: nitriles-buliding-blocks This article mentions the following:
The following compounds were prepared and tested for toxicity and effect on sarcoma, carcinoma, and myeloid leukemia in mice; compounds marked *inhibited tumor growth, || slightly promoted tumor growth, † were first synthesized here, ‡ irritated skin and mucous membranes, in each case the substituent on the methylene group of malononitrile is given: 2-(methoxycarboxy)ethyl-, 2-(ethoxycarboxy)ethyl-, 2-cyanoethyl-, methylenebis-, ethylidenebis-, heptylidenebis-, ethoxymethylene- *, aminomethylene-, glyceral- †, citral- †, tiglal- †, furfurylidene-, 5-nitrofurfurylidene- *‡, 2-thenylidene-, 5-nitro-2-thenylidene-, benzylidene- *‡, o-hydroxybenzylidene-, m-hydroxybenzylidene-, p-hydroxybenzylidene- *‡, 2,4-dihydroxybenzylidene-, 3,5-dihydroxybenzylidene-, o-methylbenzylidene- ‡, m-methylbenzylidene-, p-methylbenzylidene-, o-chlorobenzylidene- ‡, p-chlorobenzylidene- *, 2-hydroxy-5-chlorobenzylidene-, 2,4-dichlorobenzylidene-, 2,6-dichlorobenzylidene-, o-nitrobenzylidene- ‡, m-nitrobenzylidene-, p-nitrobenzylidene- *, 2,4-dinitrobenzylidene-, 2,6-dinitrobenzylidene-, 2-chloro-5-nitrobenzylidene ‡, p-methoxybenzylidene-, 2,4-dimethoxybenzylidene-, 2,5-dimethoxybenzylidene-, 3,4-dimethoxybenzylidene-, 3,4,5-trihydroxybenzylidene- †, 3,4,5-trimethoxybenzylidene- †, 3-methoxy-4-hydroxybenzylidene-, piperonal- *, cinnamal-, p-acetamidobenzylidene-, p-dimethylaminobenzylidene-, p-diethylaminobenzylidene-, 1-ethoxy-2-naphthylmethylene-, 9-anthral-, cinchoninal-, α-methylbenzylidene-, 1-methyl-2-(p-chlorophenyl)ethylidene-, 1-methyl-2-cyclopropylethylidene-, 1-methyl-2-(p-fluorophenyl)ethylidene-, 1-methyl-2-(p-methylphenyl)ethylidene-, 1-methyl-2-(p-nitrophenyl)ethylidene- *, 1-propyl-2-phenylethylidene-, 1-methyl-2-furylethylidene- *, 1-methyl-2-thienylethylidene-, isatylphenylazo- ||, p-dimethylaminophenylazo- †||, p-nitrophenylazo- ||, and p-chlorophenylazo- ||. Tested were also 1,3-dimethyl-2,2,4,4-cyclobutanetetranitrile, 2-cyano-1,4-endomethylene-4-cyclohexene ‡, and fumaronitrile. The effects were attributed to the structural properties of the particular compounds rather than to release of cyanide at different rates. Neither NaCN nor malononitrile retarded any of the tumors tested. Toxicity symptoms of the substituted malononitriles were much the same as those described for the parent compound by Heymans and Masoin (Arch. pharmacodynamie 3, 77(1897)). In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Category: nitriles-buliding-blocks).
2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts