Base-Mediated Amination of Alcohols Using Amidines was written by Zhang, Chunyan;Li, Zehua;Chen, Jianbin;Qi, Shuo;Fang, Yanchen;Zhang, Sheng;Ren, Chaoyu;Lu, Fenghong;Liang, Zuyu;Jiang, Shaohua;Jia, Xiaofei;Yu, Shuangming;Zhang, Guoying. And the article was included in Journal of Organic Chemistry in 2020.Synthetic Route of C14H12N2 This article mentions the following:
Novel and efficient base-mediated N-alkylation and amidation of amidines with alcs. have been developed, which can be carried out in one-pot reaction conditions, which allows for the synthesis of a wide range of N-alkyl amines and free amides in good to excellent yields with high atom economy. In contrast to borrowing hydrogen/hydrogen autotransfer or oxidative-type N-alkylation reactions, in which alcs. are activated by transition-metal-catalyzed or oxidative aerobic dehydrogenation, the use of amidines provides an effective surrogate of amines. This circumvents the inherent necessity in N-alkylation of an oxidant or a catalyst to be stabilized by ligands. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Synthetic Route of C14H12N2).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Synthetic Route of C14H12N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts