Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles was written by Xia, Hai-Dong;Zhang, Yan-Dong;Wang, Yan-Hui;Zhang, Chi. And the article was included in Organic Letters in 2018.Name: 2-Amino-3-chlorobenzonitrile This article mentions the following:
A readily accessible and bench-stable water-soluble hypervalent iodine(III) reagent (phenyliodonio)sulfamate (PISA, PhI+NHSO3–) with an I-N bond was synthesized, and its structure was characterized by X-ray crystallog. anal. of its monoaqua complex. N-(Alkenylphenyl)amides such as I (R = Me, Et, BuCH2, cyclopropyl, cyclohexyl, Ph, H, Et; R1 = H, Me, n-Pr, PhCH2) underwent regioselective rearrangement and oxidative cyclization mediated by PISA and H2O in MeCN to yield acylindoles such as II (R = Me, Et, BuCH2, cyclopropyl, cyclohexyl, Ph, H, Et; R1 = H, Me, n-Pr, PhCH2). Using this new method, the antiinflammatory agents indomethacin and zidometacin and 2-methylindole (an intermediate in the preparation of pravadoline) were prepared In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9Name: 2-Amino-3-chlorobenzonitrile).
2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Name: 2-Amino-3-chlorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts