Contribution to our Knowledge of the Terpenes and the Ethereal Oils. 91st Paper. (C) The Behavior of β-Cyclohexylethylamine toward Nitrous Acid was written by Wallach, O.. And the article was included in Justus Liebigs Annalen der Chemie in 1908.SDS of cas: 4435-14-7 This article mentions the following:
(Cf. Ibid.). Cyclohexylacetonitrile, b. 215°, [n]D18 1.4575 prepared from the amide of cyclohexylacetic acid, on reduction, yielded β-cyclohexylethylamine, b. 188-9°, [n]D19 1.4647. With HNO2, the latter did not form a 7-ring system, but a little cyclohexylethylene, b. 132-7°, and the alcohols C6H11.CH2.CH2OH and. C6H11.CH(OH).Me, which were separated by oxidation with chromic acid and formation of semicarbazones. In this way, cyclohexylacetaldehyde, semicarbazone, m. 132-4°, and cyclohexylmethylketone, semicarbazone, m. 172-3°, were obtained, while the acids formed in the oxidation were found to be cyclohexylacetic and adipic acids. In the experiment, the researchers used many compounds, for example, 2-Cyclohexylacetonitrile (cas: 4435-14-7SDS of cas: 4435-14-7).
2-Cyclohexylacetonitrile (cas: 4435-14-7) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.SDS of cas: 4435-14-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts